P2X7 and phospholipid signalling: the search of the "missing link" in epithelial cells.

@article{GarcaMarcos2006P2X7AP,
  title={P2X7 and phospholipid signalling: the search of the "missing link" in epithelial cells.},
  author={Mikel Garc{\'i}a-Marcos and St{\'e}phanie Pochet and Ed.D. Michael A. Marino and J. P. Dehaye},
  journal={Cellular signalling},
  year={2006},
  volume={18 12},
  pages={
          2098-104
        }
}
The purinergic receptor P2X(7) is widely expressed in epithelial cells. This receptor shares in common with the other P2X receptors the ability to form a non-selective cation channel. On the other hand, the COOH terminus of P2X(7) seems to allow this receptor to couple to a spectrum of downstream effectors responsible for the regulation of cell death and pore formation among other functions. However, the coupling of P2X(7) to these downstream effectors, as well as the identity of possible… CONTINUE READING
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