P2X6 Knockout Mice Exhibit Normal Electrolyte Homeostasis


ATP-mediated signaling is an important regulator of electrolyte transport in the kidney. The purinergic cation channel P2X6 has been previously localized to the distal convoluted tubule (DCT), a nephron segment important for Mg2+ and Na+ reabsorption, but its role in ion transport remains unknown. In this study, P2x6 knockout (P2x6-/-) mice were generated… (More)
DOI: 10.1371/journal.pone.0156803

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