P2X6 Knockout Mice Exhibit Normal Electrolyte Homeostasis

Abstract

ATP-mediated signaling is an important regulator of electrolyte transport in the kidney. The purinergic cation channel P2X6 has been previously localized to the distal convoluted tubule (DCT), a nephron segment important for Mg2+ and Na+ reabsorption, but its role in ion transport remains unknown. In this study, P2x6 knockout (P2x6-/-) mice were generated… (More)
DOI: 10.1371/journal.pone.0156803

8 Figures and Tables

Topics

  • Presentations referencing similar topics