P2X4 receptors of microglia in neuropathic pain.

  title={P2X4 receptors of microglia in neuropathic pain.},
  author={Kazuhide Inoue and Makoto Tsuda},
  journal={CNS & neurological disorders drug targets},
  volume={11 6},
We have learned various data on the role of purinoceptors (P2X4, P2X7, P2Y6 and P2Y12 receptors) expressed in spinal microglia and several factors that presumably activate microglia in neuropathic pain after peripheral nerve injury. Especially P2X4 receptors (P2X4Rs) make a critical contribution to the pain processing. P2X4Rs of microglia might be promising targets for treating neuropathic pain. A predicted therapeutic benefit of interfering with microglial P2X4Rs may be that normal pain… CONTINUE READING
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