P2X2 and P2X4 receptor expression is regulated by a GABA(A) receptor-mediated mechanism in the gerbil hippocampus.

@article{Kang2003P2X2AP,
  title={P2X2 and P2X4 receptor expression is regulated by a GABA(A) receptor-mediated mechanism in the gerbil hippocampus.},
  author={Tae-Cheon Kang and Sung-Jin An and Seung-Kook Park and In-Koo Hwang and Moo Ho Won},
  journal={Brain research. Molecular brain research},
  year={2003},
  volume={116 1-2},
  pages={
          168-75
        }
}
Fast responses to extracellular ATP are mediated by the activation of P2X receptors. Native and cloned P2X receptors are permeable to monovalent cations such as Na+ and K+ as well as divalent cations such as Ca2+. However, altered P2X receptor expression has not been definitively determined under pathological conditions, particularly in epilepsy. Here we show that, in the seizure-sensitive (SS) gerbil hippocampus, a recognized genetic epilepsy model, the expressions of both P2X2 and P2X4… CONTINUE READING

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