P2X1 stimulation promotes thrombin receptor-mediated platelet aggregation.

  title={P2X1 stimulation promotes thrombin receptor-mediated platelet aggregation.},
  author={Joseph A. Erhardt and John R Toomey and Stephen A. Douglas and Douglas G. Johns},
  journal={Journal of thrombosis and haemostasis : JTH},
  volume={4 4},
P2X1 receptors are ATP-gated channel demonstrated to be involved in multiple platelet responses, although in vitro analysis has been complicated by the effects of rapid desensitization. To further investigate potential roles of P2X1 receptors in platelet activation, the current study employed methods which maximally preserved P2X1 functionality. In preliminary in vivo studies, P2X1-deficiency reduced thrombus formation following the laser-induced, but not FeCl3-induced injury. Given the… CONTINUE READING


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