P2X1-mediated ERK2 activation amplifies the collagen-induced platelet secretion by enhancing myosin light chain kinase activation.

@article{TthZsmboki2003P2X1mediatedEA,
  title={P2X1-mediated ERK2 activation amplifies the collagen-induced platelet secretion by enhancing myosin light chain kinase activation.},
  author={Emese T{\'o}th-Zs{\'a}mboki and C{\'e}cile Oury and Heidi Cornelissen and R De vos and Jos Vermylen and Marc F Hoylaerts},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 47},
  pages={46661-7}
}
The ATP-gated P2X1 ion channel is the only P2X subtype expressed in human platelets. Via transmission electron microscopy, we found that P2X1 mediates fast, reversible platelet shape change, secretory granule centralization, and pseudopodia formation. In washed human platelets, the stable P2X1 agonist alpha,beta-methylene ATP (alpha,beta-meATP) causes rapid, transient (2-5 s), and dose-dependent myosin light chain (MLC) phosphorylation, requiring extracellular Ca2+. Phosphorylation was… CONTINUE READING
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Platelets in Thrombotic and Non-thrombotic Disorders

  • Siljander, P.R.-M, R. W. Farndale
  • 2002

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