P2X receptor antagonists for pain management: examination of binding and physicochemical properties

Abstract

Enhanced sensitivity to noxious stimuli and the perception of non-noxious stimuli as painful are hallmark sensory perturbations associated with chronic pain. It is now appreciated that ATP, through its actions as an excitatory neurotransmitter, plays a prominent role in the initiation and maintenance of chronic pain states. Mechanistically, the ability of… (More)
DOI: 10.1007/s11302-011-9272-5

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Cite this paper

@article{Gum2011P2XRA, title={P2X receptor antagonists for pain management: examination of binding and physicochemical properties}, author={Rebecca J. Gum and Brian D Wakefield and Michael F. Jarvis}, journal={Purinergic Signalling}, year={2011}, volume={8}, pages={41-56} }