P2X(7) is a scavenger receptor for apoptotic cells in the absence of its ligand, extracellular ATP.


Phagocytosis of apoptotic cells is essential during development and tissue remodeling. Our previous study has shown that the P2X(7) receptor regulates phagocytosis of nonopsonized particles and bacteria. In this study, we demonstrate that P2X(7) also mediates phagocytosis of apoptotic lymphocytes and neuronal cells by human monocyte-derived macrophages… (More)
DOI: 10.4049/jimmunol.1101178


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