P2X(4) purinoceptors mediate an ATP-activated, non-selective cation current in rabbit osteoclasts.

@article{Naemsch1999P2X4PM,
  title={P2X(4) purinoceptors mediate an ATP-activated, non-selective cation current in rabbit osteoclasts.},
  author={L N Naemsch and A. Freek Weidema and Stephen Michael Sims and T. Michael Underhill and S. Jeffrey Dixon},
  journal={Journal of cell science},
  year={1999},
  volume={112 ( Pt 23)},
  pages={4425-35}
}
Extracellular nucleotides act as signaling molecules in numerous tissues. In bone, nucleotides stimulate osteoclast formation and activity; however, the receptors and signaling mechanisms underlying these effects have yet to be identified. To identify specific P2X purinoceptor subtypes in osteoclasts, degenerate oligonucleotide primers were used to PCR-amplify DNA fragments from a rabbit osteoclast cDNA library. A 372-base-pair fragment was obtained that encoded an amino acid sequence with 88… CONTINUE READING

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