P2X(1) receptor inhibition and soluble CD39 administration as novel approaches to widen the cardiovascular therapeutic window.

@article{Fung2009P2X1RI,
  title={P2X(1) receptor inhibition and soluble CD39 administration as novel approaches to widen the cardiovascular therapeutic window.},
  author={C Y Eleanor Fung and Aaron J. Marcus and M. Johan Broekman and Martyn P. Mahaut-Smith},
  journal={Trends in cardiovascular medicine},
  year={2009},
  volume={19 1},
  pages={1-5}
}
Thrombus formation at sites of disrupted atherosclerotic plaques is a leading cause of death and disability worldwide. Although the platelet is now recognized to be a central regulator of thrombus formation, development of antiplatelet reagents that selectively target thrombosis over hemostasis represents a challenge. Existing prophylactic antiplatelet… CONTINUE READING