P2U purinergic activation leads to the cell cycle progression from the G1 to the S and M phases but not from the G0 to G1 phase in vascular smooth muscle cells in primary culture.

@article{Miyagi1996P2UPA,
  title={P2U purinergic activation leads to the cell cycle progression from the G1 to the S and M phases but not from the G0 to G1 phase in vascular smooth muscle cells in primary culture.},
  author={Yohei Miyagi and Sei Kobayashi and Aftab Ahmed and Junji Nishimura and Masashi Fukui and Hideo Kanaide},
  journal={Biochemical and biophysical research communications},
  year={1996},
  volume={222 2},
  pages={652-8}
}
The regulation of the cell cycle by extracellular UTP was investigated in rat aortic smooth muscle cells in primary culture (VSMCs) by means of an immunocytochemical analysis of cell cycle-specific nuclear antigens. UTP induced a rise in the cytosolic Ca2+ concentration ([Ca2+]i) of VSMCs, which was desensitized by pretreatment with ATP, but not with 2… CONTINUE READING