P2U agonists induce chemotaxis and actin polymerization in human neutrophils and differentiated HL60 cells.

@article{Verghese1996P2UAI,
  title={P2U agonists induce chemotaxis and actin polymerization in human neutrophils and differentiated HL60 cells.},
  author={Margrith W. Verghese and Terry Kneisler and Joyce A. Boucheron},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 26},
  pages={
          15597-601
        }
}
Human neutrophils or HL60 cells express P2U receptors and respond to micromolar concentrations of ATP, adenosine 5'-O-(thiotriphosphate) (ATPgammaS), or UTP with immediate increases in intracellular Ca2+ through activation of phosphoinositide phospholipase C (Cowen, D. S., Lazarus, H. M., Shurin, S. B., Stoll, S. E., and Dubyak, G. R. (1989) J. Clin. Invest. 83, 1651-1660). P2U agonists reportedly induce limited enzyme secretion and enhance the respiratory burst in response to chemotactic… CONTINUE READING
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