P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder.

@article{Lucae2006P2RX7AG,
  title={P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder.},
  author={Susanne Lucae and Daria Salyakina and Nicholas Barden and Mario Harvey and Bernard Gagn{\'e} and Michel Labb{\'e} and Elisabeth B. Binder and M. Uhr and Marcelo P{\'a}ez-Pereda and Inge Sillaber and Marcus Ising and Tanja Maria Br{\"u}ckl and Roselind Lieb and Florian Holsboer and Bertram M{\"u}ller-Myhsok},
  journal={Human molecular genetics},
  year={2006},
  volume={15 16},
  pages={2438-45}
}
The P2RX7 gene is located within a region on chromosome 12q24.31 that has been identified as a susceptibility locus for affective disorders by linkage and association studies. P2RX7 is a purinergic ATP-binding calcium channel expressed in neurons as well as in microglial cells in various brain regions. We investigated 29 single nucleotide polymorphisms (SNPs) within the P2RX7 gene and adjacent genes in a sample of 1000 German Caucasian patients suffering from recurrent major depressive disorder… CONTINUE READING

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