P21-dependent G 1 arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228

@article{Sandor2000P21dependentG1,
  title={P21-dependent G 1 arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228},
  author={Victor A Sandor and Adrian M. Senderowicz and Susan D. Mertins and Dan L. Sackett and Edward A. Sausville and Mikhail V. Blagosklonny and Susan E Bates},
  journal={British Journal of Cancer},
  year={2000},
  volume={83},
  pages={817 - 825}
}
Depsipeptide, FR901228, a novel cyclic peptide inhibitor of histone deacetylase with a unique cytotoxicity profile is currently in phase I clinical trials. Here we demonstrate that, in addition to G2/M arrest, FR901228 causes G1 arrest with Rb hypophosphorylation. In vitro kinase assays demonstrated no direct inhibition of CDK activity, however, an inhibition was observed in CDKs extracted from cells exposed to FR901228. Cyclin D1 protein disappeared between 6 and 12 hours after treatment with… CONTINUE READING
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