P21(WAF1/CIP1) may be a tumor suppressor after all.

  title={P21(WAF1/CIP1) may be a tumor suppressor after all.},
  author={Andrei L. Gartel},
  journal={Cancer biology & therapy},
  volume={6 8},
The cyclin-dependent kinase inhibitor p21WAF1/CIP1 was originally considered to be a tumor-suppressor because it was identified as a key mediator of p53-dependent cell cycle arrest. However, it has been suggested that p21 may also act as an oncogene because it often inhibits apoptosis. For example, deletion of p21 from p53-deficient mice resulted in longer survival and in a significantly reduced number of thymic lymphomas that was explained by higher apoptotic rates in these mice. However… CONTINUE READING


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