P2 receptors modulate respiratory rhythm but do not contribute to central CO2 sensitivity in vitro.

@article{Lorier2004P2RM,
  title={P2 receptors modulate respiratory rhythm but do not contribute to central CO2 sensitivity in vitro.},
  author={A R Lorier and K Peebles and Teresa A Brosenitsch and Dean M. Robinson and Gary D. Housley and Gregory D Funk},
  journal={Respiratory physiology & neurobiology},
  year={2004},
  volume={142 1},
  pages={27-42}
}
Multiple brainstem sites are proposed to contribute to central respiratory chemosensitivity, however, the underlying molecular mechanisms remain unknown. P2X2 subunit-containing ATP receptors, which mediate pH-sensitive currents, appear to contribute to central chemosensitivity in vivo [J. Physiol. 523 (2000) 441]. However, recent data from P2X2 knockout mice [J. Neurosci. 23 (2003) 11315] indicate that they are not essential. To further explore the role of P2 receptors in central… CONTINUE READING