P2 receptor agonists stimulate insulin release from human pancreatic islets.

@article{FernndezAlvarez2001P2RA,
  title={P2 receptor agonists stimulate insulin release from human pancreatic islets.},
  author={Josepha Fern{\'a}ndez-Alvarez and Dominique Hillaire-Buys and Marie-Madeleine Loubati{\`e}res-Mariani and Ram{\'o}n Gomis and P. Petit},
  journal={Pancreas},
  year={2001},
  volume={22 1},
  pages={
          69-71
        }
}
Although P2 receptors for adenosine 5'-triphosphate (ATP) and/or adenosine 5'-diphosphate (ADP) have been characterized in mammalian pancreatic beta cells, no evidence for an insulin-secreting effect of P2 receptor agonists has been reported as yet in humans. The present study aimed at investigating whether P2 receptor agonists could stimulate insulin release in human pancreatic islets obtained from brain-dead organ donors. Experiments were performed using different glucose concentrations and… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 37 CITATIONS

Role of purines in regulation of metabolic reprogramming

  • Purinergic Signalling
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

PI3K is involved in P2Y receptor-regulated cAMP /Epac/Kv channel signaling pathway in pancreatic β cells.

  • Biochemical and biophysical research communications
  • 2015
VIEW 1 EXCERPT
CITES BACKGROUND