P2-purinoceptors mediate both vasodilation (via the endothelium) and vasoconstriction of the isolated rat femoral artery.

@article{Kennedy1985P2purinoceptorsMB,
  title={P2-purinoceptors mediate both vasodilation (via the endothelium) and vasoconstriction of the isolated rat femoral artery.},
  author={Charles Kennedy and Dick Delbro and Geoffrey Burnstock},
  journal={European journal of pharmacology},
  year={1985},
  volume={107 2},
  pages={161-8}
}
The distribution of P1- and P2-purinoceptors in isolated rat femoral artery was studied by comparing responses to ATP, alpha, beta-methylene ATP and adenosine, both when endothelial cells were intact and when they had been removed by mechanical rubbing (as confirmed by histochemical staining and abolition of relaxations to acetylcholine). alpha, beta-Methylene ATP and ATP (but not adenosine or acetylcholine) contracted preparations at resting tone. alpha, beta-Methylene ATP was significantly… CONTINUE READING

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