P2-purinoceptor antagonists: II. Blockade of P2-purinoceptor subtypes and ecto-nucleotidases by compounds related to Evans blue and trypan blue

@article{Wittenburg1996P2purinoceptorAI,
  title={P2-purinoceptor antagonists: II. Blockade of P2-purinoceptor subtypes and ecto-nucleotidases by compounds related to Evans blue and trypan blue},
  author={Henning Wittenburg and Ralph B{\"u}ltmann and Birgit Pause and Claudia Ganter and Gerhart Kurz and Klaus Starke},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1996},
  volume={354},
  pages={491-497}
}
Effects of Evans blue and four derivatives as well as of trypan blue and four derivatives, mostly smaller fragments but two compounds with an additional ethylene bridge in the center of the molecule, were studied on contractions of the rat vas deferens elicited by α,β-methylene ATP (α,β-McATP; mediated by P2X-purinoceptors), relaxations of the carbachol-precontracted guinea-pig taenia coli elicited by adenosine 5′-O-(2-thiodiphosphate) (ADPβS; mediated by P2Y-purinoceptors), and the degradation… CONTINUE READING
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P2Purinoceptor antagonists: I. Blockade of P2-purinoceptor subtypes and ecto-nucleotidases by small aromatic isothiocyanato-sulphonates

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