P2 purinergic receptor activation enhances cardiac contractility in isolated rat and mouse hearts.

@article{Mei2001P2PR,
  title={P2 purinergic receptor activation enhances cardiac contractility in isolated rat and mouse hearts.},
  author={Qi-bing Mei and B. T. Liang},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={281 1},
  pages={H334-41}
}
Activation of P2 purinergic receptors exerts a potent positive inotropic effect in the cardiac myocyte. However, it is unknown whether its activation can also cause an increased contractility in intact heart. With the use of isolated rat and mouse hearts, the objective of the present study was to investigate the effect of P2 receptor agonist on the function of the intact heart. In both Langendorff rat hearts and working rat and mouse heart models, the P2X receptor agonist 2-methylthio-ATP (2… CONTINUE READING

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