P2 functions as a spacer in the Tetrahymena ribozyme.

  title={P2 functions as a spacer in the Tetrahymena ribozyme.},
  author={Anusch Peyman},
  journal={Nucleic acids research},
  volume={22 8},
The function of the P2 stem-loop region in the group I catalytic intron from Tetrahymena thermophila has been investigated. A comprehensive mutation analysis suggests that the bottom base pair of the P2 stem and nucleotides in the loop L2 are involved in interactions elsewhere on the intron. In addition, the P2 stem can be varied only between 9 and 11 base pairs in length. Phylogenetic evidence (3) from a sub-class of group I introns supports a model in which the P1 and P2 stems are coaxially… CONTINUE READING

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