P16 expression predicts necrotic response among patients with osteosarcoma receiving neoadjuvant chemotherapy.

@article{Borys2012P16EP,
  title={P16 expression predicts necrotic response among patients with osteosarcoma receiving neoadjuvant chemotherapy.},
  author={Dariusz Borys and Robert J Canter and Benjamin Hoch and Steve R. Martinez and Robert M. Tamurian and Brian Daragh Murphy and John W. Bishop and Andrew E Horvai},
  journal={Human pathology},
  year={2012},
  volume={43 11},
  pages={1948-54}
}
Although pathologic response to neoadjuvant chemotherapy is highly correlated with survival among patients with osteosarcoma, there are currently no established molecular markers to predict response to chemotherapy. The objective of this study was to investigate the relationship of P16 expression in pretreatment osteosarcoma tumors to pathologic necrotic response after neoadjuvant chemotherapy. A tissue microarray was created from paraffin-embedded pretreatment biopsy specimens of 40 patients… CONTINUE READING
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