P16 and p53 Expression in (Pre)Malignant Epidermal Tumors of Renal Transplant Recipients and Immunocompetent Individuals

@article{Blokx2003P16AP,
  title={P16 and p53 Expression in (Pre)Malignant Epidermal Tumors of Renal Transplant Recipients and Immunocompetent Individuals},
  author={Willeke A M Blokx and Elke M G J de Jong and Peter C M de Wilde and Johannes Bulten and Monique M G M Link and Dirk J Ruiter and Peter C M van de Kerkhof},
  journal={Modern Pathology},
  year={2003},
  volume={16},
  pages={869-878}
}
Ultraviolet (UV) radiation is a prevailing factor implicated in the etiology of keratinocytic intraepidermal neoplasia (KIN) and squamous cell carcinomas (SCCs), as evidenced by the high frequency of UV-related mutations in the p53 and p16 tumor suppressor genes. In renal transplant recipients (RTRs), immunosuppression is considered another important risk factor in the enhanced carcinogenesis in these patients. So far, effects of UV and immune status on p53 and p16 immunoexpression in SCCs and… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

P53, p16 and Ki67 immunoexpression in cutaneous squamous cell carcinoma and its precursor lesions.

  • Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • 2016
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

Effect of immunosuppressive therapy on DNA repair and cancer incidence in renal transplant recipients

T Weinstein, A Korzets, +3 authors D Zevin
  • Transplant Proc
  • 2000
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Histopathology of incipient intraepidermal squamous cell carcinoma ("actinic keratosis").

  • Journal of the American Academy of Dermatology
  • 2000
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

P16 UV mutations in human skin epithelial tumors

Nadem Soufir, Jean Pierre Molès, +6 authors Nicole Basset-Séguin
  • Oncogene
  • 1999
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

The p16INK4a/CDKN2A tumor suppressor and its relatives.

  • Biochimica et biophysica acta
  • 1998
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Cancer risk after renal transplantation in Japan.

  • International journal of cancer
  • 1997
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL