P16 Expression in Squamous Cell Carcinomas of Cervix and Bladder

  title={P16 Expression in Squamous Cell Carcinomas of Cervix and Bladder},
  author={Maureen Cioffi-Lavina and Jennifer Rose Chapman-Fredricks and Carmen R. Gomez-Fernandez and Parvin Ganjei‐Azar and Murigesan Manoharan and Merc{\'e} Jord{\'a}},
  journal={Applied Immunohistochemistry \& Molecular Morphology},
Context/Objectivep16 is a widely used immunohistochemical marker in gynecologic pathology. Strong and diffuse cytoplasmic and nuclear expression of p16 in squamous cell carcinomas (SCC) of the female genital tract is strongly associated with high-risk human papilloma virus infection and neoplasms of cervical origin. However, p16 can be expressed in other neoplasms and in several normal human tissues. Occasionally, SCCs may involve both uterine cervix and urinary bladder. Accurate identification… 


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