P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions.

  title={P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions.},
  author={Conceiç{\~a}o Maria Queiroz and T{\^a}nia Maria Correia Silva and Ven{\^a}ncio Ferreira Avancini Alves and Luisa L. Villa and Maria Cec{\'i}lia Costa and Ana Gabriela Travassos and Jos{\'e} Bouzas Ara{\'u}jo Filho and Eduardo Studart and Tatiana Cheto and Luiz Ant{\^o}nio Rodrigues de Freitas},
  journal={Pathology, research and practice},
  volume={202 2},
An immunohistochemical analysis with monoclonal antibody p16(INK4a) was performed in formalin-fixed, paraffin-embedded samples of 60 cases. The aim was to investigate in biopsies the expression of p16(INK4a) of normal uterine cervical tissue, pre-cancerous and cancerous lesions, and their relation with human papilloma virus (HPV) and HIV status. Three parameters were evaluated: percentage of p16(INK4a) positive cells, reaction intensity, and cell staining pattern. All of these parameters were… CONTINUE READING
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  • J. T. Keating, A. Cviko, +7 authors C. P. Crum
  • cyclin E and p16INK4a are complementary surrogate…
  • 2001
Highly Influential
4 Excerpts

Predictive significance of the alterations of p 16 INK 4 a , p 14 ARF , p 53 and proliferation cell nuclear antigen expression in the progression of cervical cancer

  • B.-Y. Zheng J.-L. Wang, X.-D. Li, T. Angström, M. S. Lindström, K.-L. Wallin
  • Clin . Cancer Res .
  • 2004

p16 expression and progression risk of low-grade intraepithelial neoplasia of cervix uteri

  • G. Neggri, F. Vitadello, +5 authors E. Ergarter-Vigl
  • Virchows Arch. 445
  • 2004
3 Excerpts


  • R. Klaes, A. Dener, +6 authors M. Stoler
  • von Knebel Doeberitz, p16INK4a…
  • 2002

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