P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions.

@article{Queiroz2006P16INK4aEA,
  title={P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions.},
  author={Conceiç{\~a}o Maria Queiroz and T{\^a}nia Maria Correia Silva and Ven{\^a}ncio Ferreira Avancini Alves and Luisa L. Villa and Maria Cec{\'i}lia Costa and Ana Gabriela Travassos and Jos{\'e} Bouzas Ara{\'u}jo Filho and Eduardo Studart and Tatiana Cheto and Luiz Ant{\^o}nio Rodrigues de Freitas},
  journal={Pathology, research and practice},
  year={2006},
  volume={202 2},
  pages={77-83}
}
An immunohistochemical analysis with monoclonal antibody p16(INK4a) was performed in formalin-fixed, paraffin-embedded samples of 60 cases. The aim was to investigate in biopsies the expression of p16(INK4a) of normal uterine cervical tissue, pre-cancerous and cancerous lesions, and their relation with human papilloma virus (HPV) and HIV status. Three parameters were evaluated: percentage of p16(INK4a) positive cells, reaction intensity, and cell staining pattern. All of these parameters were… CONTINUE READING
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