P100, a transcriptional coactivator, is a human homologue of staphylococcal nuclease.

@article{Ponting1997P100AT,
  title={P100, a transcriptional coactivator, is a human homologue of staphylococcal nuclease.},
  author={Chris P. Ponting},
  journal={Protein science : a publication of the Protein Society},
  year={1997},
  volume={6 2},
  pages={459-63}
}
  • Chris P. Ponting
  • Published 1997 in
    Protein science : a publication of the Protein…
Staphylococcus aureus nuclease (SNase) homologues, previously thought to be restricted to bacteria and archaea, are demonstrated by sequence analysis to be present also in eukaryotes. The human cellular coactivator p100 is shown to contain four repeats, each of which is a SNase homologue. Surprisingly, these repeats are unlikely to possess SNase-like activities as each lacks equivalent SNase catalytic residues, yet they may mediate p100's single-stranded DNA-binding function. Products of… CONTINUE READING