P1 Characterization of Large Eosinophilic Inclusions in Rat Clara Cells and the Effect of Inhaled Corticosteroid Agonist

@inproceedings{Kambara2007P1CO,
  title={P1 Characterization of Large Eosinophilic Inclusions in Rat Clara Cells and the Effect of Inhaled Corticosteroid Agonist},
  author={Taketoshi Kambara and T Mckevitt and Sarah E. Campbell and Ian Francis and Jennie Woodfine and David John Lewis and T. Ceiriog Williams},
  year={2007}
}
Large eosinophilic cytoplasmic inclusions (ECIs) are occasionally seen in the bronchiolar epithelium of control rats. Increased ECls were recently observed in rats treated with an inhaled corticosteroid. Little information is available about these ECIs. They were characterized by H&E and PAS stains, immunohistochemistry (IHC) for Clara cell specific protein (CCSP), cytochrome P450 enzymes and surfactant-associated proteins (SP-A, B and D), in situ hybridization (ISH) for CCSP mRNA and electron… CONTINUE READING

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