P02-05. All-trans retinoic acid during vaccination increases Ag-specific CD8 T cell homing to mucosal sites and improves recall responses to vaginal challenge

Abstract

Methods We investigated the use of ATRA (300 μg. intraperitoneal) as an in vivo adjuvant during vaccination of mice with adenovirus expressing the LCMV glycoprotein (gp) as a model antigen (Ad5 gp, 5 × 108 pfu, intramuscular) on the formation and migration of antigen-specific T cells to mucosal sites. To have a definable population for tracking T cell responses, we adoptively transferred 103 congenically marked P14 TCR-transgenic CD8 T cells, which are specific for the gp33-41 epitope, prior to immunization.

DOI: 10.1186/1742-4690-6-S3-P10

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Cite this paper

@article{Blattman2009P0205AR, title={P02-05. All-trans retinoic acid during vaccination increases Ag-specific CD8 T cell homing to mucosal sites and improves recall responses to vaginal challenge}, author={Joseph N Blattman and Xiutao Tan and J. Jacob van der Sande and Jeffrey S Pufnock and P. Greenberg}, journal={Retrovirology}, year={2009}, volume={6}, pages={P10 - P10} }