P.1.047 Yohimbine is a potent, partial agonist at rat and cloned, human serotonin1A receptors: A comparison to buspirone and its metabolite, 1-pyrimidinylpiperazine

@article{Gobert1997P1047YI,
  title={P.1.047 Yohimbine is a potent, partial agonist at rat and cloned, human serotonin1A receptors: A comparison to buspirone and its metabolite, 1-pyrimidinylpiperazine},
  author={Alain P. Gobert and Adrian Newman-Tancredi and Jean Michel Rivet and Valérie Audinot and Mark J Millan},
  journal={European Neuropsychopharmacology},
  year={1997},
  volume={7},
  pages={S149-S150}
}

Actions of α2 adrenoceptor ligands at α2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for α2A adrenoceptors

TLDR
The agonist DMT and the antagonist atipamezole are the ligands of choice to distinguish α2-mediated from 5- HT1A-mediated actions, whilst several of the other compounds show only low or modest selectivity for α2A over 5-HT1A receptors; caution should be exercised in experimental and clinical interpretation of the actions of traditionally employed α2 ligands.

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TLDR
This book presents a meta-anatomy of the immune system and some of the mechanisms leading to disease and its mechanisms are explained in more detail in the second chapter.

Development and validation of a stability-indicating LC-UV method for rapid analysis of buspirone in pharmaceutical dosage forms

Summary An accurate, sensitive, precise, rapid and isocratic reversed-phase HPLC (RPHPLC) method for analysis of buspirone in the bulk drug and in solid dosage formulations has been developed and

CYP2D6 CATALYZES 5-HYDROXYLATION OF 1-(2-PYRIMIDINYL)-PIPERAZINE, AN ACTIVE METABOLITE OF SEVERAL PSYCHOACTIVE DRUGS, IN HUMAN LIVER MICROSOMES

TLDR
Results indicate that polymorphic CYP2D6 is responsible for the conversion of 1-PP to HO-1-PP, the major metabolite in the human circulation and in rat brains following oral administration of buspirone.

Pharmacokinetic-Pharmacodynamic Modeling of Buspirone and Its Metabolite 1-(2-Pyrimidinyl)-piperazine in Rats

TLDR
The results of this analysis show that buspirone and 1- PP behave as partial 5-hydroxytryptamine1A agonists in vivo and that following intravenous administration the amount of 1-PP formed is too small to contribute to the hypothermic effect.