P.1.022 Role of trace amine-associated receptor 1 (TAAR1) in the modulation of the dopaminergic system and cortico-striatal signalling

@article{Espinoza2013P1022RO,
  title={P.1.022 Role of trace amine-associated receptor 1 (TAAR1) in the modulation of the dopaminergic system and cortico-striatal signalling},
  author={Stefano Espinoza and Ilya Sukhanov and Gabriele Lignani and Lucian Medrihan and Raul R Gainetdinov},
  journal={European Neuropsychopharmacology},
  year={2013},
  volume={23},
  pages={s21-s22}
}
The 5-HT6 receptor is mainly expressed in CNS regions involved in cognitive processes and has emerged as a promising target for treating cognitive deficits of schizophrenia, inasmuch as their blockade consistently enhances mnemonic performance in rodents [1]. Paradoxically, little is known about 5-HT6 receptorassociated signaling pathways, an issue we have addressed by a proteomic approach. Previously, we demonstrated that mTOR recruitment by prefrontal 5-HT6 receptors was responsible for… CONTINUE READING