P. aeruginosa quorum-sensing systems and virulence.

  title={P. aeruginosa quorum-sensing systems and virulence.},
  author={Roger S. Smith and Barbara H. Iglewski},
  journal={Current opinion in microbiology},
  volume={6 1},
Quorum sensing is an important mechanism for the regulation of genes in many Gram-negative and Gram-positive bacteria. In the opportunistic pathogen Pseudomonas aeruginosa, the absence of one or more components of the quorum-sensing system results in a significant reduction in virulence. Recent advances in the past year have demonstrated that the quorum-sensing signal molecule 3O-C(12)-HSL is also a potent stimulator of multiple eukaryotic cells and thus may alter the host response during P… CONTINUE READING

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