P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs.

@article{Ciofu2013PAI,
  title={P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs.},
  author={Oana Ciofu and Helle Krogh Johansen and Kasper Aanaes and Tina Wassermann and Morten Alhede and Christian von Buchwald and Niels H{\o}iby},
  journal={Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society},
  year={2013},
  volume={12 6},
  pages={
          729-36
        }
}
BACKGROUND Pseudomonas aeruginosa cells are present as biofilms in the paranasal sinuses and the lungs of chronically infected cystic fibrosis (CF) patients. Since different inflammatory responses and selective antibiotic pressures are acting in the sinuses compared with the lungs, we compared the adaptive profiles of mucoid and non-mucoid isolates from the two locations. METHODS We studied the genetic basis of phenotypic diversification and gene expression profiles in sequential lung and… CONTINUE READING
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Phenotypic shift in Pseudomonas aeruginosa populations from cystic fibrosis lungs after 2-week antipseudomonal treatment.

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