P-selectin mediates neutrophil rolling on histamine-stimulated endothelial cells.

  title={P-selectin mediates neutrophil rolling on histamine-stimulated endothelial cells.},
  author={David A. Jones and Omid Abbassi and L. V. Mcintire and Rodger P McEver and Clifton Smith},
  journal={Biophysical journal},
  volume={65 4},
In postcapillary venules, marginating neutrophils (PMNs) are often seen rolling along the vessel wall prior to stopping and emigrating. There is substantial evidence in vitro and in vivo that the adhesion receptors E- and L-selectin participate in this phenomenon on cytokine-stimulated endothelium, and recent evidence has shown that a closely related adhesion receptor, P-selectin, is capable of mediating neutrophil rolling on an artificial membrane. Here we demonstrate and characterize PMN… CONTINUE READING


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