P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo.

  title={P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo.},
  author={Keith E Norman and A G Katopodis and Gebhard Thoma and Frank Kolbinger and Anne E R Hicks and Matthew J. Cotter and Alan Graham Pockley and Paul G. Hellewell},
  volume={96 10},
Selectin-dependent rolling is the earliest observable event in the recruitment of leukocytes to inflamed tissues. Several glycoproteins decorated with sialic acid, fucose, and/or sulfate have been shown to bind the selectins. The best-characterized selectin ligand is P-selectin glycoprotein-1 (PSGL-1) that supports P-selectin- dependent rolling in vitro and in vivo. In vitro studies have suggested that PSGL-1 may also be a ligand for E- and L-selectins. To study the in vivo function of PSGL-1… CONTINUE READING


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