P-selectin contributes to severe experimental malaria but is not required for leukocyte adhesion to brain microvasculature.

@article{Chang2003PselectinCT,
  title={P-selectin contributes to severe experimental malaria but is not required for leukocyte adhesion to brain microvasculature.},
  author={Wen Bin Chang and Jie Li and Guang Huan Sun and Hong-li Chen and Robert D. Specian and Seth Mark Berney and Daniel Neil Granger and Henri C. van der Heyde},
  journal={Infection and immunity},
  year={2003},
  volume={71 4},
  pages={
          1911-8
        }
}
Plasmodium berghei-infected mice, a well-recognized model of experimental cerebral malaria (ECM), exhibit many of the hallmarks of a systemic inflammatory response, with organ damage in brain, lung, and kidneys. Identification of the molecules mediating pathogenesis of the inflammatory response, such as leukocyte adhesion, may lead to new therapies. Indeed, mice lacking the cell adhesion molecule P-selectin were significantly (P = 0.005) protected from death due to P. berghei malaria compared… CONTINUE READING

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CD8 -Tcell depletion ameliorates circulatory shock in Plasmodium berghei-infected mice

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