P-selectin and leukocyte microparticles are associated with venous thrombogenesis.

  title={P-selectin and leukocyte microparticles are associated with venous thrombogenesis.},
  author={Daniel Durant Myers and Angela Eileen Hawley and Diana M Farris and Shirley K. Wrobleski and Porama Thanaporn and Robert G. Schaub and Denisa D Wagner and Anjali Kumar and Thomas W. Wakefield},
  journal={Journal of vascular surgery},
  volume={38 5},
OBJECTIVES P-selectin inhibition has been found to limit venous thrombosis. We hypothesize that elevated levels of P-selectin will amplify thrombosis, mediated by procoagulant microparticles (MPs). METHODS Male mice (Mus musculus, n659), 20 to 25 grams, underwent IVC ligation to induce thrombosis. Groups consisted of wild type (WT) C57BL/6 controls, mice with high circulating levels of soluble P-selectin (CT), P-selectin gene-interrupted knockout mice (PKO), and E- and P-selectin gene… CONTINUE READING


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