P-selectin, a granule membrane protein of platelets and endothelial cells, follows the regulated secretory pathway in AtT-20 cells

@article{Koedam1992PselectinAG,
  title={P-selectin, a granule membrane protein of platelets and endothelial cells, follows the regulated secretory pathway in AtT-20 cells},
  author={J A Koedam and Elisabeth M. Cramer and Emmanuel Briend and Barbara C. Furie and Denisa D Wagner},
  journal={The Journal of Cell Biology},
  year={1992},
  volume={116},
  pages={617 - 625}
}
P-selectin (PADGEM, GMP-140, CD62) is a transmembrane protein specific to alpha granules of platelets and Weibel-Palade bodies of endotheial cells. Upon stimulation of these cells, P-selectin is translocated to the plasma membrane where it functions as a receptor for monocytes and neutrophils. To investigate whether the mechanism of targeting of P-selectin to granules is specific for megakaryocytes and endothelial cells and/or dependent on von Willebrand factor, a soluble adhesive protein that… CONTINUE READING