P pili in uropathogenic E. coli are composite fibres with distinct fibrillar adhesive tips

@article{Kuehn1992PPI,
  title={P pili in uropathogenic E. coli are composite fibres with distinct fibrillar adhesive tips},
  author={Meta J Kuehn and John M Heuser and Staffan J. Normark and Scott J Hultgren},
  journal={Nature},
  year={1992},
  volume={356},
  pages={252-255}
}
ESCHERICHIA coli is a frequent cause of several common bacterial infections in humans and animals, including urinary tract infections, bacteraemia and bacteria-related diarrhoea and is also the main cause of neonatal meningitis1. Microbial attachment to surfaces is a key event in colonization and infection and results mainly from a stereochemical fit between microbial adhesins and complementary receptors on host cells. Bacterial adhesins required for extracellular colonization by Gram-negative… CONTINUE READING
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