P-hydroxy-norephedrine as a possible mediator causing the reduction of oral intake of D-amphetamine in rats.

@article{Jaenicke1989PhydroxynorephedrineAA,
  title={P-hydroxy-norephedrine as a possible mediator causing the reduction of oral intake of D-amphetamine in rats.},
  author={B Jaenicke and Th. Heil and Helmut Coper},
  journal={Drug and alcohol dependence},
  year={1989},
  volume={23 3},
  pages={247-53}
}
In rats D-amphetamine is predominantly metabolized by hydroxylation to p-hydroxy-norephedrine (p-HNE); in guinea pigs, however, by deamination to benzoic acid. After 2-3 days on dosages of 1 mg/kg per day and more rats begin to reduce their oral intake of the stimulant whereas guinea pigs do not. In the present study we examined the hypothesis that the… CONTINUE READING