P-gp, MRP2 and OAT1/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate.

@article{Jia2016PgpMA,
  title={P-gp, MRP2 and OAT1/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate.},
  author={Yongming Jia and Zhihao Liu and Changyuan Wang and Qiang Meng and Xiaokui Huo and Qi Liu and Huijun Sun and Peng-yuan Sun and Xiaobo Yang and Xiaodong Ma and Kexin Liu},
  journal={Toxicology and applied pharmacology},
  year={2016},
  volume={306},
  pages={
          27-35
        }
}
The purpose of present study was to investigate the effect of resveratrol (Res) on altering methotrexate (MTX) pharmacokinetics and clarify the related molecular mechanism. Res significantly increased rat intestinal absorption of MTX in vivo and in vitro. Simultaneously, Res inhibited MTX efflux transport in MDR1-MDCK and MRP2-MDCK cell monolayers, suggesting that the target of drug interaction was MDR1 and MRP2 in the intestine during the absorption process. Furthermore, there was a… Expand
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References

SHOWING 1-10 OF 33 REFERENCES
MDR1 and OAT1/OAT3 Mediate the Drug-Drug Interaction between Puerarin and Methotrexate
TLDR
Co-administration of PUR enhanced MTX exposure by inhibition of intestinal MDR1 and renal OAT1/3 and the renal damage of MTX was improved by PUR, so the high level exposure ofMTX should be cautious in the clinical usage. Expand
Methotrexate-bestatin interaction: involvement of P-glycoprotein and organic anion transporters in rats.
TLDR
Findings indicate that the pharmacokinetic mechanism of interaction between MTX and bestatin occurs through co-transport by P-gp in the intestinal mucosa and OATs within the kidneys. Expand
Evaluation of the interaction between nonsteroidal anti-inflammatory drugs and methotrexate using human organic anion transporter 3-transfected cells.
TLDR
Evaluating NSAIDs that compete less with methotrexate by using the renal cell line stably expressing human OAT3 (S2-hOAT3) in vitro confirmed the pharmacokinetic interaction of metotrexate with NSAIDs in vivo and revealed the major mechanism of the interaction between methot Rexate and NSAIDs. Expand
Involvement of Multidrug Resistance-Associated Protein 1 in Intestinal Toxicity of Methotrexate
TLDR
Mrp1 determines the exposure of proliferative cells in the small intestine to MTX, followed by gastrointestinal toxicity, in mrp1(+/+) mice. Expand
Enhancement effect of resveratrol on the intestinal absorption of bestatin by regulating PEPT1, MDR1 and MRP2 in vivo and in vitro.
TLDR
Res enhances bestatin absorption by regulating PEPT1, MDR1 and MRP2 both in vivo and in vitro. Expand
Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs.
TLDR
Among the large number of transporters, cephalosporins and probenecid have the potential to produce clinically relevant OAT-mediated drug-drug interactions, whereas cyclosporin A and rifampicin may trigger OATP-mediated ones. Expand
Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the In vivo Elimination of Methotrexate and its Main Toxic Metabolite 7-hydroxymethotrexate
TLDR
Abcc2 is important for (biliary) excretion of MTX and its toxic metabolite 7OH-MTX, and Variation in ABCC2 and/or ABCC3 activity may have profound effects on the elimination and severity of toxicity ofMTX and 7OH, after MTX treatment of patients. Expand
Assessment of the Role of Renal Organic Anion Transporters in Drug-Induced Nephrotoxicity
TLDR
In the present review, only compounds generally believed to cause kidney injury either by means of direct tubular toxicity or crystal nephropathy have been considered, and the evidence for actual transport mediated by individual OATs under in vivo conditions is discussed. Expand
Proton Pump Inhibitors Inhibit Methotrexate Transport by Renal Basolateral Organic Anion Transporter hOAT3
TLDR
In vitro results suggest that PPIs inhibit [3H]MTX transport via hOAT3 inhibition, which most likely explains the drug-drug interactions between MTX and PPIs and should be considered for other OATs substrates. Expand
Enhancement effect of P-gp inhibitors on the intestinal absorption and antiproliferative activity of bestatin.
  • Xiaokui Huo, Qi Liu, +5 authors K. Liu
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2013
TLDR
The results showed that P-gp inhibitors significantly increased rat intestinal absorption of bestatin in vivo and in vitro, suggesting that the intestinal absorption and accumulation in cancer cells for bestatin were limited by P- gp-mediated efflux. Expand
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