P-glycoprotein regulates a volume-activated chloride current in bovine non-pigmented ciliary epithelial cells.

@article{Wu1996PglycoproteinRA,
  title={P-glycoprotein regulates a volume-activated chloride current in bovine non-pigmented ciliary epithelial cells.},
  author={J.-Y. Wu and Jin Zhang and Hanno Koppel and Tim J. C. Jacob},
  journal={The Journal of physiology},
  year={1996},
  volume={491 ( Pt 3)},
  pages={743-55}
}
1. The whole-cell patch clamp technique was used to investigate the swelling-activated currents in bovine non-pigmented ciliary epithelial (NPCE) cells. 2. Exposure to hypotonic solution activated a current that was blocked by 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB). The I-V relationship was shifted in the direction expected for a Cl- current when the external Cl- was replaced by gluconate (permeability ratio P(gluconate)/PCl = 0.17). The inhibition of the current evoked by voltage… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Similar Papers

Loading similar papers…