P-glycoprotein-mediated secretion of a fluorescent cyclosporin analogue by teleost renal proximal tubules.

Abstract

The transport of a fluorescent cyclosporin analogue was measured in killifish (Fundulus heteroclitus) proximal tubules by means of epifluorescence microscopy and digital image analysis. Renal cells rapidly accumulated the cyclosporin analogue from the medium and attained steady state within 60 min; luminal fluorescence increased over the first 60-90 min. At… (More)

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@article{Schramm1995PglycoproteinmediatedSO, title={P-glycoprotein-mediated secretion of a fluorescent cyclosporin analogue by teleost renal proximal tubules.}, author={U. Schramm and Gert Fricker and Roland H. Wenger and D. S. Miller}, journal={The American journal of physiology}, year={1995}, volume={268 1 Pt 2}, pages={F46-52} }