P-glycoprotein in helminths: function and perspectives for anthelmintic treatment and reversal of resistance.

@article{Kerboeuf2003PglycoproteinIH,
  title={P-glycoprotein in helminths: function and perspectives for anthelmintic treatment and reversal of resistance.},
  author={Dominique Kerboeuf and William J. Blackhall and R. S. Kaminsky and Georg von Samson-Himmelstjerna},
  journal={International journal of antimicrobial agents},
  year={2003},
  volume={22 3},
  pages={332-46}
}
Infestation with parasitic helminths is a common problem in human populations of third world countries and is ubiquitous in livestock and other domestic animals. The cell-membrane efflux pump, P-glycoprotein (Pgp), appears to contribute to anthelmintic resistance. Pgp have been identified from both phyla of parasitic helminths, Platyhelmintha and Nematoda, and alterations in expression levels and allele frequencies of Pgp in anthelmintic-resistant populations have been observed in nematodes… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

Reduced efficacy of albendazole against Ascaris lumbricoides in Rwandan schoolchildren

International journal for parasitology. Drugs and drug resistance • 2017
View 3 Excerpts

Similar Papers

Loading similar papers…