P-glycoprotein has differential effects on the disposition of statin acid and lactone forms in mdr1a/b knockout and wild-type mice.

@article{Chen2007PglycoproteinHD,
  title={P-glycoprotein has differential effects on the disposition of statin acid and lactone forms in mdr1a/b knockout and wild-type mice.},
  author={Cuiping Chen and Jian Lin and Teresa A. Smolarek and Larry M. Tremaine},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2007},
  volume={35 10},
  pages={1725-9}
}
In the present study we examined the disposition of atorvastatin, lovastatin, and simvastatin in acid and lactone forms and pravastatin in acid form in multidrug-resistant gene (mdr1a/b) knockout (KO), and wild-type (WT) mice. Each statin was administered s.c. to mdr1a/b KO and WT mice at 3.0 mg/kg (n > or = 3 mice/time point). Blood, brain, and liver samples were harvested at 0, 0.5, 1.5, and 3 h postdose. Plasma and tissue concentrations of the acid and lactone (only the acid form was… CONTINUE READING

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