P-glycoprotein functions as an immunomodulator in healthy human primary nasal epithelial cells.

@article{Bleier2013PglycoproteinFA,
  title={P-glycoprotein functions as an immunomodulator in healthy human primary nasal epithelial cells.},
  author={Benjamin Saul Bleier and Angela L Nocera and Hufsa Iqbal and John D Hoang and Rachel E. Feldman and Xue Han},
  journal={International forum of allergy & rhinology},
  year={2013},
  volume={3 6},
  pages={433-8}
}
BACKGROUND P-glycoprotein (P-gp) is an adenosine triphosphate (ATP)-dependent efflux pump that confers chemotherapeutic resistance in cancer cells. Recent studies suggest that P-gp may also function as an immunomodulator through regulation of cytokine transport. Sinonasal epithelial cells have been recognized as drivers of local innate and adaptive immunity and are known to overexpress P-gp in the setting of inflammation. The objective of this study is to therefore determine whether P-gp… CONTINUE READING
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