P-glycoprotein expression influences the result of 99mTc-MIBI scintigraphy in tertiary hyperparathyroidism.

@article{Chudziski2005PglycoproteinEI,
  title={P-glycoprotein expression influences the result of 99mTc-MIBI scintigraphy in tertiary hyperparathyroidism.},
  author={Witold Chudziński and Justyna Niderla and Zofia Lasiecka and Grzegorz M. Wilczynski and Barbara G{\'o}rnicka and Aleksander Wasiutyński and Joanna Mączewska and Malgorzata Kobylecka and Leszek Kr{\'o}licki and Magdalena Durlik and E. B. Nowacka and Maciej Lazarczyk and Piotr J. Dziunycz and Lukasz Milewski and Ireneusz Nawrot and Tomasz Grzela},
  journal={International journal of molecular medicine},
  year={2005},
  volume={16 2},
  pages={
          215-9
        }
}
Precise localization of parathyroid glands using 99mTc-labeled hexakis-2-methoxyisobutylisonitrile (99mTc-MIBI) scintigraphy could be affected by various biological factors. There is increasing evidence that radiotracer retention could be controlled by members of multidrug resistance (MDR) system, especially P-glycoprotein (P-gp). Since the role of P-gp in tertiary hyperparathyroidism (T-HPTH) scintigraphic studies is poorly recognized, the aim of the study was to compare the correlation… CONTINUE READING

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