P-glycoprotein expression in human retinal pigment epithelium.

  title={P-glycoprotein expression in human retinal pigment epithelium.},
  author={Brian G. Kennedy and Nancy J. Mangini},
  journal={Molecular vision},
PURPOSE The retinal pigment epithelium (RPE) is a transporting epithelial monolayer that controls hydration and composition of the subretinal space. P-glycoprotein is an ATP-binding cassette transport protein known to transport a wide range of hydrophobic compounds. The expression of P-glycoprotein in barrier epithelial cells suggests that it could serve a normal protective function, possibly clearing potentially harmful substances from sensitive compartments, like the subretinal space. The… CONTINUE READING


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