P-glycoprotein expression in human retinal pigment epithelium.

@article{Kennedy2002PglycoproteinEI,
  title={P-glycoprotein expression in human retinal pigment epithelium.},
  author={Brian G. Kennedy and Nancy J. Mangini},
  journal={Molecular vision},
  year={2002},
  volume={8},
  pages={422-30}
}
PURPOSE The retinal pigment epithelium (RPE) is a transporting epithelial monolayer that controls hydration and composition of the subretinal space. P-glycoprotein is an ATP-binding cassette transport protein known to transport a wide range of hydrophobic compounds. The expression of P-glycoprotein in barrier epithelial cells suggests that it could serve a normal protective function, possibly clearing potentially harmful substances from sensitive compartments, like the subretinal space. The… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 59 references

Intravitreal daunomycin induces multidrug resistance in proliferative vitreoretinopathy.

Investigative ophthalmology & visual science • 1998
View 3 Excerpts
Highly Influenced

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine.

Proceedings of the National Academy of Sciences of the United States of America • 1997
View 4 Excerpts
Highly Influenced

The P-glycoprotein multidrug transporter.

General pharmacology • 1996
View 5 Excerpts
Highly Influenced

Expression and function of P-glycoprotein in a mouse kidney cell line.

The American journal of physiology • 1995
View 4 Excerpts
Highly Influenced

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