P-glycoprotein-expressing tumor cells are resistance to anticancer drugs in human gastrointestinal cancer

@article{Hotta1999PglycoproteinexpressingTC,
  title={P-glycoprotein-expressing tumor cells are resistance to anticancer drugs in human gastrointestinal cancer},
  author={Tsukasa Hotta and Hiroshi Tanimura and Makoto Iwahashi and Masaji Tani and Tsukasa Tsunoda and Kohei Noguchi and Shizuma Mizobata and Kazuo Arii and Hiroshi Terasawa and Mikihito Nakamori and Hiroki Yamaue},
  journal={Surgery Today},
  year={1999},
  volume={29},
  pages={591-596}
}
The resistance to doxorubicin (DOX) by some tumor cells is mainly due to the effect of P-glycoprotein encoded by the multidrug resistance-1 (mdr1) gene. We tried to prove the correlations between P-glycoprotein expression and the sensitivity for anticancer drugs including DOX and other cytotoxic drugs that are currently used for gastrointestinal cancer patients. We quantified the P-glycoprotein expression by flow cytometry techniques, and the sensitivity for anticancer drugs using a tetrazolium… CONTINUE READING
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