P-glycoprotein-deficient mice have proximal tubule dysfunction but are protected against ischemic renal injury.

@article{Huls2007PglycoproteindeficientMH,
  title={P-glycoprotein-deficient mice have proximal tubule dysfunction but are protected against ischemic renal injury.},
  author={Miriam Huls and Cornelis Kramers and Elena Levtchenko and Martijn J Wilmer and Henry B. P. M. Dijkman and Leo A. J. Kluijtmans and Jos{\'e} W. A. van der Hoorn and Frans G. M. Russel and Rosalinde Masereeuw},
  journal={Kidney international},
  year={2007},
  volume={72 10},
  pages={1233-41}
}
The multidrug resistance gene 1 product, P-glycoprotein (P-gp), is expressed in several excretory organs, including the apical membrane of proximal tubules. After inducing acute renal failure, P-gp expression is upregulated and this might be a protective function by pumping out toxicants and harmful products of oxidative stress. We characterized renal function of P-gp knockout mice and studied its consequences in renal ischemic damage. Compared with wild-type mice, knockout mice have a lower… CONTINUE READING

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