P-glycoprotein as multidrug transporter: a critical review of current multidrug resistant cell lines.

@article{Nielsen1992PglycoproteinAM,
  title={P-glycoprotein as multidrug transporter: a critical review of current multidrug resistant cell lines.},
  author={D. Nielsen and T. Skovsgaard},
  journal={Biochimica et biophysica acta},
  year={1992},
  volume={1139 3},
  pages={
          169-83
        }
}
  • D. Nielsen, T. Skovsgaard
  • Published 1992
  • Biology, Medicine
  • Biochimica et biophysica acta
  • MDR has been studied extensively in mammalian cell lines. According to usual practice, the MDR phenotype is characterized by the following features: cross resistance to multiple chemotherapeutic agents (lipophilic cations), defective intracellular drug accumulation and retention, overexpression of P-gp (often accompanied by gene amplification), and reversal of the phenotype by addition of calcium channel blockers. An hypothesis for the function of P-gp has been proposed in which P-gp acts as a… CONTINUE READING
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    References

    SHOWING 1-10 OF 101 REFERENCES
    Modulation of the expression of a multidrug resistance gene (mdr-1/P-glycoprotein) by differentiating agents.
    • 205
    Genes amplified and overexpressed in human multidrug-resistant cell lines.
    • 160
    • PDF
    Characterization of a K562 multidrug-resistant cell line.
    • 32
    • PDF