P-glycoprotein as multidrug transporter: a critical review of current multidrug resistant cell lines.

  title={P-glycoprotein as multidrug transporter: a critical review of current multidrug resistant cell lines.},
  author={D. Nielsen and T. Skovsgaard},
  journal={Biochimica et biophysica acta},
  volume={1139 3},
  • D. Nielsen, T. Skovsgaard
  • Published 1992
  • Biology, Medicine
  • Biochimica et biophysica acta
  • MDR has been studied extensively in mammalian cell lines. According to usual practice, the MDR phenotype is characterized by the following features: cross resistance to multiple chemotherapeutic agents (lipophilic cations), defective intracellular drug accumulation and retention, overexpression of P-gp (often accompanied by gene amplification), and reversal of the phenotype by addition of calcium channel blockers. An hypothesis for the function of P-gp has been proposed in which P-gp acts as a… CONTINUE READING
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